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Mechanism of action

VARGATEF®: A triple mode of action

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  • VARGATEF® targets 3 signalling pathways crucial to angiogenesis regulation and escape mechanisms1-4
  • Targeting these multiple receptors including potential escape pathways may prevent the tumour from finding an alternative route to grow and spread4-5
 
​​VEGFR  = vascular endothelial growth factor receptor
PDGFR = platelet-derived growth factor receptor
FGFR = fibroblast growth factor receptor
References
  1. Reck M. Expert Rev Anticancer Ther. 2015; 15:579-594
  2. VARGATEF® SmPC
  3. Hilberg F et al. Cancer Res 2008; 68:4774-4782
  4. Rashdan S, Hanna N. Expert Opin Pharmacother 2014; 15:729-39
  5. Santos ES et al. Invest New Drugs 2012; 30:1261-9
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